The surprising way scientists say smokers can facilitate the attraction of nicotine

Has Nicotine’s addiction finally met her in her match?

Smoking is one of the most harmful habits to adopt because it causes lung cancer, heart disease and some other direct problems. However, over 22% of the world’s population uses tobacco, according to the World Health Organization, with more than 8 million people die of it every year.

Approximately half of us adult snmokers try to abandon each year, but usually less than 10% actually succeed – mainly the second to problems that manage intense desires and with withdrawal symptoms.

The US Food and Drug Administration has approved two medicines designed to help reduce tobacco desires – Bupropia (marketed as wellbutrin) and Varenicline (Chantix).

Now, scientists in Korea have been found that the process of Parkinson’s drug drug can relieve the physical symptoms of nicotine attraction, such as vibration and decreased mobility.

“This study presents new opportunities for the treatment of tobacco cessation by alleviating the outages caused by the symptoms of withdrawal,” my brain disorder center of the Korean Institute of Science and Technology said. “It provides an additional treatment option along with bupropion and varenicline.”

Parkinson’s patients have an imbalance between neurotransmitters acetylcholine and dopamine within the stratum, a part of the brain deeply involved in movement control and processing rewards.

Dopamine disappearance is the leading cause of motor symptoms associated with Parkinson.

Procyclidine works to restore balance by blocking the activity of cholinergic interneurons, nerve cells that release acetylcholine. The drug treats muscle stiffness, vibrations and spasms in Parkinson’s patients.

My group found that giving a single low dose of procyclidine to mice that exhibit symptoms of nicotine attraction decrease their vibration by over 50%.

The idea is that nicotine is structural -like acetylcholine, allowing it to connect to receptors to cholinergic interneurons. Team experiments showed that interneuron printing reset the level of dopamine in the striatum.

Dopamine is known as the “feel good” hormone, and nicotine in the cigarettes stimulates its release. Quitters often experience desires because they lose dopamine hit. Restoring dopamine would facilitate withdrawal.

“By moving forward, we aim to deepen understanding of addiction mechanisms, including nicotine and develop effective therapy,” IM said.

The results of my study were published in November in the journal Advanced Science.

Since Procyclidine is already approved in the US and other places, the next step is to make sure not to interact with established smoking treatments and see if one-two marking can help people “