Biohackers live from mantra, “test, do not guess” – understand how well your cells and organs are aging, so you know the lifestyle changes to make and the additions to get for a longer, healthier life.
Some tests analyze the intestinal bacteria or proteins in the blood to predict healthy aging, while the other focus on changes in DNA.
Recently I gave one of these DNA sets a Manhattan-based Toy Health sells a 249 dollar pages test that evaluates biological age and makes recommendations to help improve results.
“Many people who wrote us or I have talked that they used the test as an inspiration to make really, truly powerful life changes,” Adiv Johnson, head of scientific affairs and education in Telly Health, told me.
The test, called Tallyage, launched in 2023. A new study revised by colleagues by the Tally Health Team confirmed that dozens of diseases and health conditions, such as pulmonary fibrosis, non-alcoholic fatty liver disease, cancers and tumors, increase the likelihood of a higher punishment.
“We are trying to learn more about that kind of lower things or increase the results,” Johnson said.
How does Tallyage work
Almost every cell in our body contains the same basic group of DNA.
Tallyage measures DNA methylation, where chemical labels called methyl groups are joined by DNA, affecting how genes are read and expressed without supporting the basic sequence of DNA.
Diet, exercise, stress and smoking are some of the lifestyle factors that can affect DNA methylation, a foundation of epigenetics. The alignment of methylation varies between different types of cells and tissues.
“We look at hundreds of thousands with DNA methylation sites across the genome,” Johnson explained.
“You get a value that tells you how methylized or indelibed a particular site is in your sample,” he added. “Basically what you get is a production of a large number of values that the algorithm can translate into an era.”
The results usually reach within six weeks of sampling.
Why a page swab?
Researchers have used everything, from blood to saliva to biological age – even sweat is being tested.
Johnson said a page swab is as accurate as collecting blood and more accessible – can easily be done at home.
“Both types of tissues are so applicable to predicting the epigenetic era, but an advantage of a page swab is just its pain,” Johnson said.
Tally Health generally recommends testing once or twice a year – sometimes it takes months or even a major living change to reflect on results.
How is Tallyage compared to other aging tests
There is no biomarker indicator that finally reveals how well we are aging, so fraud for consumers is to find the right measure.
From the tests I took, Tally Health gave me the most optimistic results.
I am 42 years old and have a meeting a little less than 37.
Johnson said I am at 5.7% better of all users and 3.2% higher of peers.
So I felt quite confident when I agreed to have my eyes photographed for a test of aging at the world conference of last week’s Biohackers. I was shocked when I took an age of 46.
“If you take 10 different tests from 10 different companies, you will get 10 different results,” assured Johnson.
“And the range will be gigantic. It will surely be like a 20-year-old range in the tests,” he continued. “The reason for this is that companies are using different algorithms, and not all of these tests are optimized for useful forecast.”
He emphasized that the recent research of Tally Health, published in the magazine Geroscience, demonstrated that his model stood among the rest for the correlation of the disease.
He also noted that tissues in different organs – like those on the cheek and eyes – age at different rates.
Changes of popular living
Tallyage users are encouraged to do a lifestyle study in their diet, fitness routine, sleep, mental health and daytime habits for suggestions on how to keep their outcome. My lifestyle of the millennial age of Mom was rated “moderately healthy” – “There is room for improvement.
Tally health membership ($ 129 a month) includes personalized action plans, tests every six months, supplements and discounts of products.
“We’ve seen many people as the challenge of trying to overcome their age,” Johnson said. “Kind is a kind like gamidating in terms of it, it’s really a pleasure to get a result and optimize it.”
Removal of cigarettes and boza are among the main changes. Johnson said “Tally Health data suggests any amount of alcohol increases the chance of being older” – especially 15 or more drinks per week.
What is next for Tally’s health?
In her new work, Tally Health linked exposure to PBB-153, a man-made chemical used as a flame retardant, at an older age. The US stopped GDP-153 in the 1970s after it was accidentally mixed in animal feed in Michigan, contacting the food supply.
“We also saw that people who have untreated HIV are more likely to be epigenectically older, but when treated with antiretrovirals, they are new to untreated groups,” Johnson said.
“These are the kind of things that are helping us to understand what types of interventions and variables are associated with an older or younger epigenetic era,” He continued, “and we also identified the methylation sites in our model that was importing these types.”
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